Assessment Of MicroRNA-451, P-Selectin, Haemoglobin Levels, And Platelet Counts In Steady-State Individuals With Haemoglobin-S Variants In Jalingo, Nigeria
DOI: https://dx.doi.org/10.4314/amls.v3i2.11
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ABSTRACT
BACKGROUND: Sickle cell disease (SCD) is a prevalent monogenic disorder characterized by abnormal hemoglobin and associated with various clinical complications. Homozygous sickle cell (HbSS) erythrocytes have differential expression of many erythrocytic microRNAs (miRNAs). Elevated levels of miR- 451 and let-7i-5p have been reported in HbSS and HbAS erythrocytes. P-selectin, a member of a family of adhesive proteins, plays an essential role in the initial recruitment of leukocytes and in the recruitment and aggregation of platelets to the site of injury during inflammation. This interaction is thought to contribute to the inflammation of SCD.