Serum Ferritin, P53 and IgE interplay in patients with Systemic Lupus Erythematosus (SLE)
DOI: doi-org-10-51374-annalsmls-2024-3-1-0005
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Abstract
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is fast becoming a common condition among blacks, including Nigerians. Its prevalence, frequency, and severity may be influenced by immune status, race, genetic, and environmental factors. This study investigated the interaction of serum ferritin, IgE, p53 and a few inflammatory markers (CRP and RA) in SLE in our studypopulation.
Materials and Methods: A total of eighty consented male and female subjects consisting of 30 ANA and Anti-ds-DNA positive as classical SLE cases, 42 ANA and Anti-ds-DNA negative controls, and 8 ANA positive and anti-ds-DNA negative were recruited into the study. Serum samples were analyzed for Ferritin and Total IgE by a chemiluminescence method and p53, RF, and CRP by ELISA techniques. Statistical analysis was carried out using the IBM SPSS incorporated, version 20, (Illinois, Chicago).
Results: Ferritin and p53 levels were significantly increased (t = 0.001, p< 0.05 and t = 0.008, p < 0.05 respectively), in the SLE positive cases compared to the Negative control and ANA positive control participants. The levels of total IgE, RF and CRP were not significantly different in the three groups, (t = 0.247, 0.153 and 0.440 respectively, p> 0.05). However, serum IgE levels were increased in the male participants compared to the female and correlated with age. The levels of CRP correlated with p53 and age while ferritin was observed to correlate with p53, CRP, and RF levels.
Conclusion: This study showed gender prevalence and preponderance to the female population, ratio of females to males, 4:1, with a mean age of 33.83 years (male) and 34.71 years (female). The elevated levels of ferritin and p53 along with
the correlation among SLE participants suggests an important intersection between inflammation and apoptosis, with a promising application as biomarkers, possibly for the monitoring of the prognosis and management of this disease.
Keywords: C-reactive protein (CRP), Ferritin, Rheumatoid Factor (RF), Systemic Lupus Erythematosus (SLE), Total IgE, p53.